Area - 15.782 km2 (6.093 sq mi)
Population - 84,157
The area was settled as a frontier for Thonburi when King Taksin established Thonburi as the new capital. Later administration reform placed Rat Burana as an amphoe of Thonburi province. It was then moved to Nakhon Khuan Khan province (now Amphoe Phra Pradaeng) until the province was demoted to an amphoe of Samut Prakan Province. It was then moved back to Thonburi province until Thonburi and Bangkok were merged. It is now a district of Bangkok. In 1998, part of Rat Burana left to form a new district, Thung Khru.
In 2015, Baan Khru Noi, "One of Bangkok's oldest" charity homes for children, was scheduled to close after 30 years.